Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERAP2 | Q6P179 | 8/20 | 0.55 |
| ▸ | IL1RN | P18510 | 7/20 | 0.55 |
| ▸ | ERAP1 | Q9NZ08 | 7/20 | 0.55 |
| ▸ | LNPEP | Q9UIQ6 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TACR1 | P25103 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7986614 | 0.91 | MAPK1 (0.54) | ERAP2ERAP1LNPEPMAPK1SMN1; SMN2 | |
| SCHEMBL7976001 | 0.91 | ERAP2 (0.56) | ERAP2IL1RNERAP1LNPEPMAPK1 | |
| SCHEMBL7990236 | 0.83 | MAPK1 (0.53) | ERAP2IL1RNERAP1MAPK1SMN1; SMN2 | |
| SCHEMBL7990814 | 0.82 | MAPK1 (0.53) | MAPK1SMN1; SMN2MEN1MAPTKMT2A | |
| SCHEMBL8807886 | 0.81 | MAPK1 (0.55) | ERAP2ERAP1LNPEPMAPK1SMN1; SMN2 | |
| SCHEMBL7990465 | 0.81 | MAPK1 (0.55) | ERAP2ERAP1LNPEPMAPK1SMN1; SMN2 | |
| SCHEMBL7994217 | 0.81 | MAPK1 (0.55) | ERAP2ERAP1LNPEPMAPK1SMN1; SMN2 | |
| SCHEMBL7987378 | 0.80 | MAPK1 (0.53) | MAPK1SMN1; SMN2MEN1MAPTKMT2A | |
| SCHEMBL7988051 | 0.79 | SMN1; SMN2 (0.55) | ERAP2IL1RNMAPK1SMN1; SMN2TACR1 | |
| SCHEMBL7987404 | 0.79 | KMT2A (0.51) | ERAP2IL1RNMAPK1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288105-B1 | COMPOUNDS SUCH AS (S)-2-(4-((2-AMINO-3-HYDROXY-1-OXOPROPYL)AMINO)PHENYL)-6-HYDRO XY-3-(3-METHOXY-4-(1-PYRROLIDINYLMETHYL)BENZYL)BENZO(B)THIOPHE NE | ELI LILLY AND COMPANY | 2001-09-11 | — | — | US | disclosed |
| US-6207686-B1 | FOR THERAPY OF HYPERTENSION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| WO-1996015109-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-23 | — | — | WO | disclosed |