Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.74 |
| ▸ | GAK | O14976 | 3/20 | 0.74 |
| ▸ | FBP1 | P09467 | 2/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.74 |
| ▸ | MAPT | P10636 | 1/20 | 0.74 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.62 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.62 |
| ▸ | ILK | Q13418 | 2/20 | 0.62 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.62 |
| ▸ | BUB1 | O43683 | 2/20 | 0.62 |
| ▸ | STK10 | O94804 | 2/20 | 0.62 |
| ▸ | ABL1 | P00519 | 2/20 | 0.62 |
| ▸ | LCK | P06239 | 2/20 | 0.62 |
| ▸ | LYN | P07948 | 2/20 | 0.62 |
| ▸ | RET | P07949 | 2/20 | 0.62 |
| ▸ | SRC | P12931 | 2/20 | 0.62 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.62 |
| ▸ | FECH | P22830 | 2/20 | 0.62 |
| ▸ | KDR | P35968 | 2/20 | 0.62 |
| ▸ | FLT3 | P36888 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7978339 | 0.87 | EGFR (0.78) | EGFRGAKFBP1ALDH1A1MAPT | |
| SCHEMBL667895 | 0.86 | EGFR (1.00) | EGFRGAKFBP1ALDH1A1MAPT | |
| SCHEMBL7977085 | 0.85 | EGFR (0.72) | EGFRGAKFBP1MAPTERBB2 | |
| Hydrochloric Acid SCHEMBL1507455 | 0.85 | EGFR (0.98) | EGFRGAKFBP1ALDH1A1MAPT | |
| SCHEMBL644810 | 0.84 | EGFR (0.83) | EGFRGAKFBP1ALDH1A1MAPT | |
| SCHEMBL7982711 | 0.83 | EGFR (0.71) | EGFRGAKFBP1ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL28286584 | 0.83 | EGFR (0.82) | EGFRGAKFBP1ALDH1A1MAPT | |
| SCHEMBL15946889 | 0.83 | EGFR (0.85) | EGFRGAKFBP1ALDH1A1MAPT | |
| SCHEMBL1507690 | 0.82 | EGFR (0.83) | EGFRGAKFBP1ALDH1A1MAPT | |
| SCHEMBL13285584 | 0.82 | EGFR (0.83) | EGFRGAKFBP1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0837063-A1 | 4-Aminoquinazoline derivatives | PFIZER INC. (US) | 1998-04-22 | — | — | EP | claimed |
| US-6225318-B1 | 4-aminoquinazolone derivatives | PFIZER INC | 2001-05-01 | — | — | US | disclosed |
| EP-0837063-A1 | 4-Aminoquinazoline derivatives | PFIZER INC. (US) | 1998-04-22 | — | — | EP | disclosed |