Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.61 |
| ▸ | FLT1 | P17948 | 1/20 | 0.61 |
| ▸ | FLT4 | P35916 | 1/20 | 0.61 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 6/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7505010 | 0.94 | KDR (0.58) | KDRFLT1FLT4CYP11B1CYP11B2 | |
| SCHEMBL7507277 | 0.93 | KDR (0.58) | KDRFLT1FLT4CYP11B1CYP11B2 | |
| SCHEMBL7516192 | 0.91 | KDR (0.54) | KDRFLT1FLT4CYP11B1CYP11B2 | |
| SCHEMBL7504838 | 0.90 | KDR (0.54) | KDRFLT1FLT4CYP11B1CYP11B2 | |
| SCHEMBL7976092 | 0.89 | KDR (0.70) | KDRFLT1FLT4CYP11B1CYP11B2 | |
| SCHEMBL7547790 | 0.88 | KDR (0.68) | KDRFLT1FLT4CYP11B1CYP11B2 | |
| SCHEMBL7550053 | 0.87 | KDR (0.75) | KDRFLT1FLT4PDE4BPDE4D | |
| SCHEMBL7550357 | 0.87 | KDR (0.78) | KDRFLT1FLT4KCNH2PRKACA | |
| SCHEMBL7553739 | 0.87 | KDR (0.54) | KDRFLT1FLT4CYP11B1CYP11B2 | |
| SCHEMBL7552655 | 0.86 | KDR (0.54) | KDRFLT1FLT4CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |