Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 4/20 | 0.72 |
| ▸ | JAK2 | O60674 | 14/20 | 0.61 |
| ▸ | JAK3 | P52333 | 8/20 | 0.58 |
| ▸ | PTK2 | Q05397 | 6/20 | 0.58 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.54 |
| ▸ | RORC | P51449 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2144825 | 0.88 | JAK1 (0.80) | JAK1JAK2JAK3PTK2EGLN2 | |
| SCHEMBL3192870 | 0.86 | JAK2 (0.63) | JAK1JAK2JAK3PTK2RORC | |
| SCHEMBL3208463 | 0.86 | JAK2 (0.70) | JAK1JAK2JAK3PTK2RORC | |
| SCHEMBL3205526 | 0.85 | JAK2 (0.58) | JAK1JAK2JAK3PTK2 | |
| SCHEMBL7980632 | 0.84 | JAK1 (1.00) | JAK1JAK2JAK3PTK2EGLN2 | |
| SCHEMBL7975885 | 0.83 | EGLN2 (0.80) | JAK1JAK2JAK3PTK2EGLN2 | |
| SCHEMBL3301043 | 0.80 | JAK1 (0.48) | JAK1JAK2JAK3PTK2EGLN2 | |
| SCHEMBL3204030 | 0.80 | JAK2 (0.75) | JAK1JAK2JAK3PTK2 | |
| SCHEMBL17685333 | 0.80 | JAK2 (0.51) | JAK1JAK2JAK3PTK2 | |
| SCHEMBL16248942 | 0.79 | JAK2 (0.60) | JAK1JAK2JAK3PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010188-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES. | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |