Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 14/20 | 0.62 |
| ▸ | JAK3 | P52333 | 8/20 | 0.60 |
| ▸ | PTK2 | Q05397 | 7/20 | 0.60 |
| ▸ | JAK1 | P23458 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2144118 | 0.91 | JAK2 (0.64) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL2145769 | 0.91 | JAK2 (0.64) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL3215814 | 0.90 | JAK2 (0.61) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL2144259 | 0.89 | JAK2 (0.54) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL7977780 | 0.87 | JAK2 (0.82) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL3263824 | 0.86 | JAK2 (0.69) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL3200947 | 0.84 | JAK2 (0.83) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL2144631 | 0.84 | JAK2 (0.62) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL3203231 | 0.83 | JAK2 (0.58) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL3204783 | 0.83 | JAK2 (0.53) | JAK2JAK3PTK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010188-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES. | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |