Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 20/20 | 0.58 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15417584 | 0.87 | PDE9A (0.59) | PDE9APDE1C | |
| SCHEMBL12399237 | 0.87 | PDE9A (0.59) | PDE9APDE1C | |
| SCHEMBL12400494 | 0.87 | PDE9A (0.59) | PDE9APDE1C | |
| SCHEMBL15417585 | 0.87 | PDE9A (0.59) | PDE9APDE1C | |
| SCHEMBL7877895 | 0.87 | PDE9A (0.59) | PDE9APDE1C | |
| SCHEMBL7877425 | 0.87 | PDE9A (0.59) | PDE9APDE1C | |
| SCHEMBL7884548 | 0.87 | PDE9A (0.59) | PDE9APDE1C | |
| SCHEMBL7996231 | 0.85 | PDE9A (0.67) | PDE9APDE1C | |
| SCHEMBL15417579 | 0.84 | PDE9A (0.77) | PDE9APDE1C | |
| SCHEMBL12400503 | 0.84 | PDE9A (0.77) | PDE9APDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009121919-A1 | 1-HETEROCYCLYL-1,5-DIHYDRO-PYRAZOLO[3,4-D] PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS PDE9A MODULATORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-10-08 | — | — | WO | disclosed |