Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.51 |
| ▸ | CDK2 | P24941 | 6/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.49 |
| ▸ | CDK4 | P11802 | 4/20 | 0.49 |
| ▸ | INSR | P06213 | 4/20 | 0.46 |
| ▸ | IGF1R | P08069 | 6/20 | 0.46 |
| ▸ | EGFR | P00533 | 3/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7980583 | 0.86 | CDK2 (0.50) | HDAC1CDK2CCNE1CDK4 | |
| SCHEMBL10252325 | 0.86 | CDK2 (0.49) | HDAC1CDK2CCNE1CDK4INSR | |
| SCHEMBL10252165 | 0.85 | CDK2 (0.49) | HDAC1CDK2CCNE1CDK4INSR | |
| SCHEMBL10252196 | 0.83 | CDK2 (0.51) | HDAC1CDK2CCNE1CDK4 | |
| SCHEMBL10252153 | 0.82 | CDK2 (0.50) | HDAC1CDK2CCNE1CDK4INSR | |
| SCHEMBL7978154 | 0.82 | CDK2 (0.50) | HDAC1CDK2CCNE1CDK4INSR | |
| SCHEMBL7964023 | 0.82 | CDK2 (0.50) | HDAC1CDK2CCNE1CDK4 | |
| SCHEMBL699844 | 0.82 | HDAC1 (0.59) | HDAC1CDK2CCNE1CDK4INSR | |
| SCHEMBL7978108 | 0.82 | CDK2 (0.62) | HDAC1CDK2CCNE1CDK4INSR | |
| SCHEMBL7965090 | 0.82 | CDK2 (0.49) | HDAC1CDK2CCNE1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010009155-A2 | FUSED HETEROCYCLYC INHIBITOR COMPOUNDS | GILEAD COLORADO, INC. (US) | 2010-01-21 | — | — | WO | disclosed |