Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 12/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.34 |
| ▸ | CDK2 | P24941 | 4/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | MPL | P40238 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL792675 | 0.83 | TYK2 (0.51) | TYK2JAK2CDK2EGFRERBB2 | |
| Hydrochloric Acid SCHEMBL11898764 | 0.83 | TYK2 (0.51) | TYK2JAK2CDK2EGFRERBB2 | |
| SCHEMBL11898778 | 0.81 | TYK2 (0.49) | TYK2 | |
| Hydrochloric Acid SCHEMBL793483 | 0.80 | TYK2 (0.49) | TYK2 | |
| SCHEMBL791626 | 0.77 | TYK2 (0.73) | TYK2JAK2LCK | |
| Hydrochloric Acid SCHEMBL11898680 | 0.77 | TYK2 (0.72) | TYK2JAK2LCK | |
| SCHEMBL793466 | 0.75 | TYK2 (0.59) | TYK2JAK2CDK2LCKEGFR | |
| SCHEMBL793110 | 0.74 | TYK2 (0.66) | TYK2JAK2CDK2KDRJAK1 | |
| SCHEMBL793559 | 0.74 | TYK2 (0.80) | TYK2JAK2LCK | |
| SCHEMBL793045 | 0.73 | TYK2 (0.57) | TYK2JAK2LCKEGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616072-A1 | AZABENZOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012035039-A1 | AZABENZOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-22 | — | — | WO | disclosed |