Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 3/20 | 0.54 |
| ▸ | EGFR | P00533 | 11/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | GAK | O14976 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | CLK1 | P49759 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7980352 | 1.00 | RET (0.54) | RETEGFRERBB2KDRGAK | |
| SCHEMBL7978490 | 0.91 | RET (0.62) | RETEGFRERBB2KDRABCG2 | |
| SCHEMBL7978493 | 0.91 | RET (0.62) | RETEGFRERBB2KDRABCG2 | |
| SCHEMBL7980425 | 0.89 | RET (0.61) | RETEGFRERBB2KDRABCG2 | |
| SCHEMBL7980428 | 0.89 | RET (0.61) | RETEGFRERBB2KDRABCG2 | |
| Hydrochloric Acid SCHEMBL4386000 | 0.86 | RET (0.67) | RETEGFRERBB2KDRABCG2 | |
| SCHEMBL7976955 | 0.85 | EGFR (0.59) | RETEGFRERBB2KDRGAK | |
| SCHEMBL7976950 | 0.85 | EGFR (0.59) | RETEGFRERBB2KDRGAK | |
| SCHEMBL7979991 | 0.84 | EGFR (0.63) | RETEGFRERBB2KDRABCG2 | |
| SCHEMBL7978417 | 0.84 | RET (0.60) | RETEGFRERBB2KDRABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6225318-B1 | 4-aminoquinazolone derivatives | PFIZER INC | 2001-05-01 | — | — | US | disclosed |
| EP-0837063-A1 | 4-Aminoquinazoline derivatives | PFIZER INC. (US) | 1998-04-22 | — | — | EP | disclosed |