SCHEMBL7980858

SCHEMBL7980858

CS(=O)(=O)Nc1cc([C@@H](O)CNCCOc2ccc3c4c(oc3c2)CCCC4)ccc1O

nearest known ligand 0.55

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ADRB3 P13945 20/20 0.55
ADRA1A P35348 3/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7967369 1.00 ADRB3 (0.55) ADRB3ADRA1A
SCHEMBL7967364 1.00 ADRB3 (0.55) ADRB3ADRA1A
Hydrochloric Acid SCHEMBL7984010 0.99 ADRB3 (0.54) ADRB3ADRA1A
Hydrochloric Acid SCHEMBL7984008 0.99 ADRB3 (0.54) ADRB3ADRA1A
SCHEMBL7977267 0.92 ADRB3 (0.47) ADRB3ADRA1A
SCHEMBL7980642 0.92 ADRB3 (0.47) ADRB3ADRA1A
SCHEMBL7977270 0.92 ADRB3 (0.47) ADRB3ADRA1A
Hydrochloric Acid SCHEMBL7980727 0.91 ADRB3 (0.46) ADRB3ADRA1A
Hydrochloric Acid SCHEMBL7967386 0.91 ADRB3 (0.46) ADRB3ADRA1A
Hydrochloric Acid SCHEMBL7967389 0.91 ADRB3 (0.46) ADRB3ADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6172099-B1 CARBAZOLE, DIBENZOFURAN, OR DIBENZOTHIOPHENE DERIVATIVES; DIETETICS, ANTIDIABETIC AGENTS; ANTILIPEMICS ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 2001-01-09 US claimed
EP-0997458-A1 NOVEL TRICYCLIC COMPOUNDS HAVING SATURATED RINGS AND MEDICINAL COMPOSITIONS CONTAINING THE SAME Asahi Kasei Kogyo Kabushiki Kaisha (JP) 2000-05-03 EP claimed
US-6172099-B1 CARBAZOLE, DIBENZOFURAN, OR DIBENZOTHIOPHENE DERIVATIVES; DIETETICS, ANTIDIABETIC AGENTS; ANTILIPEMICS ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 2001-01-09 US disclosed
EP-0997458-A1 NOVEL TRICYCLIC COMPOUNDS HAVING SATURATED RINGS AND MEDICINAL COMPOSITIONS CONTAINING THE SAME Asahi Kasei Kogyo Kabushiki Kaisha (JP) 2000-05-03 EP disclosed