Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 11/20 | 0.79 |
| ▸ | EGFR | P00533 | 5/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.51 |
| ▸ | KDR | P35968 | 6/20 | 0.51 |
| ▸ | SRC | P12931 | 5/20 | 0.51 |
| ▸ | RET | P07949 | 2/20 | 0.51 |
| ▸ | FLT4 | P35916 | 2/20 | 0.51 |
| ▸ | CIT | O14578 | 1/20 | 0.51 |
| ▸ | GAK | O14976 | 1/20 | 0.51 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.51 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.51 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.51 |
| ▸ | STK17B | O94768 | 1/20 | 0.51 |
| ▸ | STK10 | O94804 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7981107 | 0.96 | LCK (0.85) | LCKEGFRKDRSRCRET | |
| SCHEMBL7969589 | 0.94 | LCK (0.70) | LCKEGFRERBB2 | |
| SCHEMBL7970742 | 0.92 | LCK (0.93) | LCK | |
| SCHEMBL7979668 | 0.90 | LCK (0.75) | LCKSRC | |
| SCHEMBL7987001 | 0.88 | LCK (1.00) | LCK | |
| SCHEMBL7980325 | 0.88 | LCK (1.00) | LCK | |
| SCHEMBL7987285 | 0.85 | LCK (0.80) | LCK | |
| SCHEMBL7983711 | 0.85 | LCK (0.94) | LCKSRC | |
| SCHEMBL7980264 | 0.85 | LCK (0.75) | LCK | |
| SCHEMBL7982912 | 0.84 | LCK (0.76) | LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | claimed |
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | disclosed |