Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23467051 | 0.90 | KDM4E (0.47) | KDM4EHSD17B10POLBTSHRALDH1A1 | |
| SCHEMBL15687748 | 0.89 | KDM4E (0.43) | KDM4EHSD17B10POLBTSHRALDH1A1 | |
| SCHEMBL28018803 | 0.86 | KDM4E (0.41) | KDM4EHSD17B10POLBTSHRALDH1A1 | |
| SCHEMBL3604215 | 0.85 | SLC22A12 (0.44) | POLBSLC22A12ALDH1A1HPGDSSTR5 | |
| SCHEMBL7382833 | 0.85 | SLC22A12 (0.56) | KDM4EPOLBSLC22A12HPGDKMT2A | |
| SCHEMBL3606625 | 0.84 | SLC22A12 (0.39) | KDM4EHSD17B10POLBSLC22A12ALDH1A1 | |
| SCHEMBL15687369 | 0.83 | KDM4E (0.40) | KDM4EHSD17B10POLBTSHRALDH1A1 | |
| SCHEMBL3612834 | 0.83 | SLC22A12 (0.39) | KDM4EPOLBSLC22A12ALDH1A1HPGD | |
| SCHEMBL27272748 | 0.83 | SLC22A12 (0.44) | KDM4EHSD17B10TSHRSLC22A12ALDH1A1 | |
| SCHEMBL15687424 | 0.83 | KDM4E (0.44) | KDM4EHSD17B10POLBTSHRSLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6262040-B1 | Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the production of tumor necrosis factor (TNF) | PFIZER INC | 2001-07-17 | — | — | US | disclosed |
| CN-1234031-A | Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the prodn. of tumor necrosis factor (TNF) | PFIZER (US) | 1999-11-03 | — | — | CN | disclosed |