Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 8/20 | 0.61 |
| ▸ | HRH1 | P35367 | 8/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | ME2 | P23368 | 1/20 | 0.47 |
| ▸ | ME1 | P48163 | 1/20 | 0.47 |
| ▸ | ME3 | Q16798 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7979703 | 0.84 | HRH2 (0.66) | HRH2HRH1HRH3 | |
| SCHEMBL7976458 | 0.82 | HRH2 (0.67) | HRH2HRH1HRH3 | |
| SCHEMBL7982282 | 0.81 | HRH2 (0.68) | HRH2HRH1HRH3 | |
| SCHEMBL7243576 | 0.81 | HRH2 (0.70) | HRH2HRH1SIGMAR1KDM4EMEN1 | |
| SCHEMBL7244127 | 0.79 | HRH2 (0.86) | HRH2HRH1 | |
| SCHEMBL7245149 | 0.76 | HRH1 (0.68) | HRH2HRH1HRH3 | |
| SCHEMBL492219 | 0.76 | HRH3 (0.75) | KDM4EMEN1KMT2AHRH3 | |
| SCHEMBL2628226 | 0.74 | FFAR1 (0.52) | MEN1KMT2A | |
| SCHEMBL25090009 | 0.73 | HRH2 (0.60) | HRH2HRH1HRH3DRD2ME2 | |
| SCHEMBL23291268 | 0.72 | HRH3 (0.64) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001066534-A2 | CYCLIC AND BICYCLIC DIAMINO HISTAMINE-3 RECEPTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 2001-09-13 | — | — | WO | disclosed |