Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 5/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.44 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.44 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7982266 | 1.00 | RAF1 (0.44) | RAF1LRRK2NOX4PIK3C3GSK3B | |
| SCHEMBL5774040 | 0.85 | RAF1 (0.62) | RAF1LRRK2PIK3C3MAPTNPC1 | |
| SCHEMBL5774037 | 0.85 | RAF1 (0.62) | RAF1LRRK2PIK3C3MAPTNPC1 | |
| SCHEMBL1395230 | 0.85 | LRRK2 (0.62) | RAF1LRRK2PIK3C3MAPTPOLB | |
| SCHEMBL1395231 | 0.85 | LRRK2 (0.62) | RAF1LRRK2PIK3C3MAPTPOLB | |
| SCHEMBL1394771 | 0.77 | LRRK2 (0.51) | RAF1LRRK2PIK3C3MAPTPOLB | |
| SCHEMBL1394772 | 0.77 | LRRK2 (0.51) | RAF1LRRK2PIK3C3MAPTPOLB | |
| SCHEMBL5080407 | 0.76 | LRRK2 (0.67) | RAF1LRRK2NOX4GSK3BEGFR | |
| SCHEMBL1395025 | 0.76 | LRRK2 (0.67) | RAF1LRRK2NOX4GSK3BEGFR | |
| SCHEMBL5771261 | 0.75 | LRRK2 (0.59) | RAF1LRRK2PIK3C3MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6268391-B1 | Benzylidene-1,3-dihydro-indol-2-one derivatives a receptor tyrosine kinase inhibitors, particularly of Raf kinases | GLAXO WELLCOME INC. | 2001-07-31 | — | — | US | disclosed |