Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.68 |
| ▸ | RAB9A | P51151 | 4/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | HTT | P42858 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.56 |
| ▸ | RELA | Q04206 | 1/20 | 0.56 |
| ▸ | STAT3 | P40763 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | GALR3 | O60755 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7351475 | 0.91 | NPC1 (0.73) | NPC1RAB9AKDM4EHSD17B10HPGD | |
| SCHEMBL6599812 | 0.83 | KDM4E (0.70) | NPC1RAB9AKDM4EHSD17B10HPGD | |
| SCHEMBL29687771 | 0.79 | KDM4E (0.71) | NPC1RAB9AKDM4EHSD17B10HPGD | |
| SCHEMBL7349354 | 0.79 | KDM4E (0.71) | NPC1RAB9AKDM4EHSD17B10HPGD | |
| SCHEMBL4763784 | 0.78 | KDM4E (0.61) | NPC1RAB9AKDM4EHSD17B10HPGD | |
| SCHEMBL959364 | 0.77 | KDM4E (1.00) | NPC1RAB9AKDM4EHSD17B10HPGD | |
| SCHEMBL29709972 | 0.77 | KDM4E (1.00) | NPC1RAB9AKDM4EHSD17B10HPGD | |
| SCHEMBL7348329 | 0.77 | NPC1 (0.65) | NPC1RAB9AKDM4EHSD17B10HPGD | |
| SCHEMBL958967 | 0.77 | KDM4E (0.72) | NPC1RAB9AKDM4EHSD17B10HPGD | |
| SCHEMBL7982729 | 0.76 | KDM4E (0.56) | NPC1RAB9AKDM4EHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6214834-B1 | ANGIOGENESIS INHIBITORS; ANTIINFLAMMATORY AGENTS; ANTICANCER AGENTS | DUPONT PHARMACEUTICALS COMPANY | 2001-04-10 | — | — | US | disclosed |
| US-5760028-A | TREATING CANCER METASTASIS, DIABETIC RETINOPATHY, NEOVASCULAR GLAUCOMA, THROMBOSIS, RESTENOSIS, OSTEOPOROSIS, MACULAR DEGENERATION | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-06-02 | — | — | US | disclosed |