Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 19/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7983218 | 0.99 | LCK (0.49) | LCKFGFR1KDR | |
| SCHEMBL7981130 | 0.97 | LCK (0.52) | LCK | |
| SCHEMBL7982713 | 0.94 | LCK (0.51) | LCK | |
| SCHEMBL7987015 | 0.88 | LCK (0.43) | LCK | |
| SCHEMBL7983694 | 0.85 | LCK (0.56) | LCK | |
| SCHEMBL7983881 | 0.84 | FGFR1 (0.47) | LCKFGFR1KDR | |
| SCHEMBL7981252 | 0.82 | LCK (0.49) | LCK | |
| SCHEMBL7981784 | 0.82 | LCK (0.44) | LCKFGFR1 | |
| SCHEMBL7969625 | 0.81 | LCK (0.41) | LCK | |
| SCHEMBL7981496 | 0.80 | LCK (0.47) | LCKFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | claimed |
| WO-1999009845-A1 | IMIDAZOQUINOXALINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-04 | — | — | WO | claimed |
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | disclosed |