Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | PDE8B | O95263 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PREP | P48147 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21597007 | 0.88 | PDE8B (0.47) | ATMKDM1APDE8BHSD17B10HPGD | |
| SCHEMBL7986307 | 0.88 | PDE8B (0.47) | ATMKDM1APDE8BHSD17B10HPGD | |
| SCHEMBL32687105 | 0.87 | ATM (0.44) | ATMPDE8BHSD17B10CHEK2SMN1; SMN2 | |
| SCHEMBL20828130 | 0.87 | ATM (0.60) | ATMKDM1APDE8BHSD17B10CHEK2 | |
| SCHEMBL2345014 | 0.87 | ATM (0.51) | ATMKDM1APDE8BHSD17B10CHEK2 | |
| SCHEMBL2354644 | 0.87 | ATM (0.51) | ATMKDM1APDE8BHSD17B10CHEK2 | |
| SCHEMBL1551631 | 0.87 | ATM (0.51) | ATMKDM1APDE8BHSD17B10CHEK2 | |
| SCHEMBL20828126 | 0.87 | ATM (0.60) | ATMKDM1APDE8BHSD17B10CHEK2 | |
| SCHEMBL2687901 | 0.87 | ATM (0.60) | ATMKDM1APDE8BHSD17B10CHEK2 | |
| SCHEMBL6597261 | 0.86 | PDE8B (0.47) | ATMKDM1APDE8BHSD17B10CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265434-B1 | ANTIINFLAMMATORY AGENTS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |