Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 18/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | TOP2A | P11388 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7979976 | 0.93 | LCK (1.00) | LCKALDH1A1TOP2ASMN1; SMN2 | |
| SCHEMBL7979842 | 0.86 | LCK (0.74) | LCKALDH1A1TOP2ASMN1; SMN2 | |
| SCHEMBL7969983 | 0.81 | LCK (0.66) | LCKSMN1; SMN2 | |
| SCHEMBL7969987 | 0.81 | LCK (0.66) | LCKSMN1; SMN2 | |
| SCHEMBL4931040 | 0.77 | LCK (1.00) | LCKSMN1; SMN2 | |
| SCHEMBL7980767 | 0.75 | LCK (1.00) | LCK | |
| SCHEMBL7980884 | 0.75 | LCK (1.00) | LCK | |
| SCHEMBL7981902 | 0.75 | LCK (1.00) | LCK | |
| SCHEMBL7969769 | 0.74 | LCK (0.84) | LCKSMN1; SMN2 | |
| SCHEMBL7970323 | 0.74 | LCK (0.67) | LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | claimed |
| WO-1999009845-A1 | IMIDAZOQUINOXALINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-04 | — | — | WO | claimed |
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | disclosed |