Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 6/20 | 0.60 |
| ▸ | GRIA2 | P42262 | 6/20 | 0.60 |
| ▸ | GRIA3 | P42263 | 6/20 | 0.60 |
| ▸ | GRIA4 | P48058 | 6/20 | 0.60 |
| ▸ | GRIN2D | O15399 | 4/20 | 0.50 |
| ▸ | GRIN3B | O60391 | 4/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.50 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.50 |
| ▸ | GRIN2C | Q14957 | 4/20 | 0.50 |
| ▸ | GRIN3A | Q8TCU5 | 4/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29798454 | 0.75 | GRIA1 (1.00) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL678318 | 0.75 | GRIA1 (1.00) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL8672228 | 0.75 | GRIA1 (0.56) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL7568176 | 0.74 | GRIN2D (0.50) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL6780272 | 0.74 | GRIA1 (0.45) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL7103934 | 0.73 | GRIA1 (0.81) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL9092889 | 0.73 | GRIA1 (0.54) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| Hydrochloric Acid SCHEMBL9093386 | 0.72 | GRIA1 (0.53) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL6780551 | 0.72 | GRIA1 (1.00) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL6784577 | 0.72 | GRIA1 (1.00) | GRIA1GRIA2GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6197771-B1 | NERVOUS SYSTEM DISORDERS; ANTIISCHEMIC AGENTS; ALZHEIMER'SDISEASE; PARKINSON'S DISEASE; HUNTINGTON'S DISEASE | WARNER-LAMBERT COMPANY | 2001-03-06 | — | — | US | disclosed |
| US-6057313-A | TREATING CENTRAL NERVOUS SYSTEM DISORDERS | WARNER-LAMBERT COMPANY (US) | 2000-05-02 | — | — | US | disclosed |