Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 4/20 | 0.61 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.61 |
| ▸ | GRIA3 | P42263 | 4/20 | 0.61 |
| ▸ | GRIA4 | P48058 | 4/20 | 0.61 |
| ▸ | MTHFD2 | P13995 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7983673 | 0.90 | GRIA1 (0.59) | GRIA1GRIA2GRIA3GRIA4MTHFD2 | |
| Benzamide SCHEMBL8472482 | 0.86 | GRIA1 (0.55) | GRIA1GRIA2GRIA3GRIA4MTHFD2 | |
| SCHEMBL7980231 | 0.85 | GRIA1 (0.58) | GRIA1GRIA2GRIA3GRIA4ALDH1A1 | |
| SCHEMBL8472488 | 0.82 | GRIA1 (0.57) | GRIA1GRIA2GRIA3GRIA4SMN1; SMN2 | |
| SCHEMBL8474636 | 0.82 | GRIA1 (0.50) | GRIA1GRIA2GRIA3GRIA4MTHFD2 | |
| SCHEMBL7984623 | 0.78 | GRIA1 (0.60) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL8477906 | 0.78 | GRIA1 (0.66) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL7970099 | 0.77 | GRIA1 (0.56) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL8476223 | 0.77 | GRIA1 (0.63) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL678318 | 0.76 | GRIA1 (1.00) | GRIA1GRIA2GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057313-A | TREATING CENTRAL NERVOUS SYSTEM DISORDERS | WARNER-LAMBERT COMPANY (US) | 2000-05-02 | — | — | US | claimed |
| WO-1996028445-A1 | NOVEL GLUTAMATE (AMPA/KAINATE) RECEPTOR ANTAGONISTS: N-SUBSTITUTED FUSED AZACYCLOALKYLQUINOXALINEDIONES | WARNER-LAMBERT COMPANY (US) | 1996-09-19 | — | — | WO | claimed |
| US-6197771-B1 | NERVOUS SYSTEM DISORDERS; ANTIISCHEMIC AGENTS; ALZHEIMER'SDISEASE; PARKINSON'S DISEASE; HUNTINGTON'S DISEASE | WARNER-LAMBERT COMPANY | 2001-03-06 | — | — | US | disclosed |
| US-6057313-A | TREATING CENTRAL NERVOUS SYSTEM DISORDERS | WARNER-LAMBERT COMPANY (US) | 2000-05-02 | — | — | US | disclosed |
| WO-1996028445-A1 | NOVEL GLUTAMATE (AMPA/KAINATE) RECEPTOR ANTAGONISTS: N-SUBSTITUTED FUSED AZACYCLOALKYLQUINOXALINEDIONES | WARNER-LAMBERT COMPANY (US) | 1996-09-19 | — | — | WO | disclosed |