Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 7/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.44 |
| ▸ | KHK | P50053 | 3/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7987557 | 0.82 | KHK (0.52) | PDE4APDE4BPDE4DPDE4CKHK | |
| SCHEMBL27428244 | 0.79 | ESR1 (0.40) | PDE4APDE4BPDE4DADORA3ADORA2A | |
| SCHEMBL3600682 | 0.76 | PIK3CD (0.42) | PDE4APDE4BPDE4DPDE4CKHK | |
| SCHEMBL683162 | 0.75 | ESR1 (0.40) | PDE4APDE4BPDE4DADORA3ADORA2A | |
| SCHEMBL3167730 | 0.75 | PDE4A (0.41) | PDE4APDE4BPDE4DADORA3ADORA2A | |
| SCHEMBL3600710 | 0.75 | KHK (0.39) | PDE4APDE4BPDE4DPDE4CKHK | |
| SCHEMBL6796557 | 0.74 | PTGDR2 (0.47) | PDE4APDE4BPDE4DPDE4CESR1 | |
| SCHEMBL6185088 | 0.74 | ESR1 (0.42) | PDE4APDE4BPDE4DADORA3ADORA2A | |
| SCHEMBL27540455 | 0.73 | PDE4A (0.45) | PDE4APDE4BPDE4DADORA3ADORA2A | |
| SCHEMBL3602939 | 0.73 | ESR1 (0.41) | PDE4APDE4BPDE4DPDE4CESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2193808-A1 | Synergistic combination | Nycomed GmbH (DE) | 2010-06-09 | — | — | EP | disclosed |
| EP-1849468-A2 | Pharmaceutical composition of a pde4 or a pde3/4 inhibitor and a histamine receptor antagonist | Nycomed GmbH (DE) | 2007-10-31 | — | — | EP | disclosed |
| WO-2004047817-A1 | PDE4 AND PDE3/4 INHIBITORS FOR USE IN THE TREATMENT OF CACHEXIA | ALTANA PHARMA AG (DE) | 2004-06-10 | — | — | WO | disclosed |
| WO-2003024488-A2 | COMBINATION OF A PDE INHIBITOR AND A LEUKOTRIENE RECEPTOR ANTAGONIST | ALTANA PHARMA AG (DE) | 2003-03-27 | — | — | WO | disclosed |
| US-6262040-B1 | Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the production of tumor necrosis factor (TNF) | PFIZER INC | 2001-07-17 | — | — | US | disclosed |