SCHEMBL7984166

SCHEMBL7984166

COc1cc2nc(Nc3c(C)cc(C)cc3C)c3cncn3c2cc1OC

nearest known ligand 0.81

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
LCK P06239 18/20 0.81
SRC P12931 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7987691 0.92 LCK (0.70) LCK
SCHEMBL7970815 0.92 LCK (0.76) LCK
SCHEMBL7982985 0.91 LCK (0.78) LCKSRC
SCHEMBL7983098 0.89 LCK (1.00) LCKSRC
SCHEMBL7981105 0.88 LCK (0.71) LCK
SCHEMBL7981082 0.87 LCK (0.72) LCK
SCHEMBL7980577 0.87 LCK (0.78) LCKSRC
SCHEMBL7980179 0.85 LCK (0.76) LCK
SCHEMBL7983740 0.84 LCK (0.78) LCK
SCHEMBL7981489 0.84 LCK (0.73) LCK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6235740-B1 AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS BRISTOL-MYERS SQUIBB CO. 2001-05-22 US claimed
WO-1999009845-A1 IMIDAZOQUINOXALINE PROTEIN TYROSINE KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 1999-03-04 WO claimed
US-6235740-B1 AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS BRISTOL-MYERS SQUIBB CO. 2001-05-22 US disclosed