Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 20/20 | 0.69 |
| ▸ | CDK1 | P06493 | 19/20 | 0.69 |
| ▸ | CCNB1 | P14635 | 18/20 | 0.69 |
| ▸ | CCNA2 | P20248 | 18/20 | 0.69 |
| ▸ | CCNA1 | P78396 | 18/20 | 0.69 |
| ▸ | CCNB2 | O95067 | 17/20 | 0.69 |
| ▸ | CCNB3 | Q8WWL7 | 17/20 | 0.69 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.69 |
| ▸ | CLK1 | P49759 | 1/20 | 0.69 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.69 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.69 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3462331 | 0.82 | CDK2 (1.00) | CDK2CDK1CCNB1CCNA2CCNA1 | |
| SCHEMBL31439122 | 0.82 | CDK2 (0.72) | CDK2CDK1CCNB1CCNA2CCNA1 | |
| SCHEMBL6266766 | 0.82 | CDK2 (0.72) | CDK2CDK1CCNB1CCNA2CCNA1 | |
| SCHEMBL7153314 | 0.80 | CDK1 (0.62) | CDK2CDK1CCNB1CCNA2CCNA1 | |
| SCHEMBL6266042 | 0.80 | CDK2 (1.00) | CDK2CDK1CCNB1CCNA2CCNA1 | |
| SCHEMBL6268103 | 0.77 | CDK2 (1.00) | CDK2CDK1CCNB1CCNA2CCNA1 | |
| SCHEMBL13038782 | 0.75 | CDK1 (0.65) | CDK2CDK1CCNB1CCNA2CCNA1 | |
| SCHEMBL6791647 | 0.74 | CDK2 (1.00) | CDK2CDK1CCNB1CCNA2CCNA1 | |
| SCHEMBL6792130 | 0.73 | CDK2 (1.00) | CDK2CDK1CCNB1CCNA2CCNA1 | |
| SCHEMBL6785454 | 0.73 | CCNA2 (1.00) | CDK2CDK1CCNB1CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303618-B1 | ADMINISTERING PURINE COMPOUND WHICH INHIBITS CYCLIC DEPENDENT KINASE ACTIVITY FOR THERAPY OF TUMOR OR OTHER CELL PROLIFERATION DISORDER | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 2001-10-16 | — | — | US | disclosed |