Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.50 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.49 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.49 |
| ▸ | CCR2 | P41597 | 2/20 | 0.48 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3540595 | 0.85 | AKR1C3 (0.56) | ALDH1A1TSHRHPGDKMT2ASMN1; SMN2 | |
| SCHEMBL181066 | 0.85 | AKR1C3 (0.56) | ALDH1A1TSHRHPGDKMT2ASMN1; SMN2 | |
| SCHEMBL2965273 | 0.80 | SLC18A3 (0.81) | SLC18A3ALDH1A1GRIN2BCYP2D6CYP2C19 | |
| SCHEMBL20599602 | 0.80 | AKR1C3 (0.50) | ALDH1A1HPGDSMN1; SMN2NPSR1 | |
| SCHEMBL21851141 | 0.78 | TP53 (0.56) | ALDH1A1KDM4ETSHRKMT2ASMN1; SMN2 | |
| SCHEMBL24434987 | 0.77 | AKR1C3 (0.69) | ALDH1A1 | |
| SCHEMBL3543298 | 0.77 | AKR1C3 (0.69) | ALDH1A1 | |
| SCHEMBL25618622 | 0.76 | TP53 (0.46) | ALDH1A1KDM4EKMT2ASMN1; SMN2GAA | |
| SCHEMBL64063 | 0.75 | KDM4E (0.56) | SLC18A3ALDH1A1KDM4ECCR2TRPV6 | |
| SCHEMBL7477011 | 0.75 | SLC18A3 (0.59) | SLC18A3ALDH1A1KDM4EGRIN2BCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235731-B1 | REDUCING BLOOD LIPIDS, SUGARS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-22 | — | — | US | disclosed |
| EP-0915888-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | Takeda Chemical Industries, Ltd. (JP) | 1999-05-19 | — | — | EP | disclosed |
| WO-1997040051-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-10-30 | — | — | WO | disclosed |