Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 10/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31607767 | 0.77 | HDAC6 (0.36) | ALDH1A1SIGMAR1CYP4F2CYP4A11 | |
| SCHEMBL6474034 | 0.77 | POLB (0.50) | TNFMAPTALDH1A1 | |
| SCHEMBL11861074 | 0.73 | CYP1A2 (0.53) | TNFGAAALDH1A1HSD17B10HRH2 | |
| SCHEMBL3310783 | 0.72 | HDAC6 (0.41) | ALDH1A1CYP4F2CYP4A11 | |
| SCHEMBL6474441 | 0.72 | POLB (0.52) | ALDH1A1 | |
| SCHEMBL3309074 | 0.71 | CYP1A2 (0.40) | GAAALDH1A1HSD17B10 | |
| SCHEMBL31389960 | 0.71 | P2RY14 (0.35) | CYP4F2CYP4A11 | |
| SCHEMBL31389811 | 0.71 | MAPT (0.37) | MAPT | |
| SCHEMBL1127701 | 0.69 | PAOX (0.51) | TNFALDH1A1HRH2HRH1 | |
| SCHEMBL30887203 | 0.68 | CYP1A2 (0.47) | TNFGAAALDH1A1HRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207663-B1 | AS INHIBITORS OF BONE RESORPTION, TUMOR GROWTH, TUMOR METASTASIS, OR INFLAMMATION, OR FOR THE TREATMENT OR PROPHYLAXIS OF CARDIOVASCULAR DISORDERS, NEPHROPATHIES OR RETINOPATHIES | HOECHST ATKIENGESELLSCHAFT (DE) | 2001-03-27 | — | — | US | disclosed |