SCHEMBL7987223

SCHEMBL7987223

O=C1c2ccccc2C(O[C@@H]2C=CCCC2)(c2ccc(Cl)cc2)N1Cc1ccc([N+](=O)[O-])cc1

nearest known ligand 0.77

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MDM2 Q00987 20/20 0.77
TP53 P04637 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21539708 1.00 MDM2 (0.77) MDM2TP53
SCHEMBL7993016 0.87 MDM2 (0.82) MDM2TP53
SCHEMBL2453993 0.87 MDM2 (1.00) MDM2TP53
SCHEMBL12305351 0.87 MDM2 (1.00) MDM2TP53
SCHEMBL1819475 0.85 MDM2 (1.00) MDM2TP53
SCHEMBL7978553 0.85 MDM2 (1.00) MDM2TP53
SCHEMBL12305394 0.85 MDM2 (1.00) MDM2TP53
SCHEMBL7984671 0.84 MDM2 (1.00) MDM2TP53
SCHEMBL1820536 0.84 MDM2 (1.00) MDM2TP53
SCHEMBL1835800 0.82 MDM2 (1.00) MDM2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009156735-A2 NEW THERAPEUTIC AGENTS CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2009-12-30 WO disclosed