Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 12/20 | 0.79 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7975434 | 0.94 | CCR3 (0.72) | CCR3SLC1A2CYP2D6THRB | |
| SCHEMBL7932368 | 0.92 | CCR3 (0.73) | CCR3SLC1A2THRB | |
| SCHEMBL7934845 | 0.91 | CCR3 (0.70) | CCR3 | |
| SCHEMBL7986617 | 0.91 | CCR3 (0.71) | CCR3 | |
| SCHEMBL7936440 | 0.89 | CCR3 (0.75) | CCR3ALDH1A1GAATSHRLMNA | |
| SCHEMBL18840917 | 0.89 | CCR3 (1.00) | CCR3SLC1A2 | |
| SCHEMBL7926039 | 0.88 | CCR3 (0.65) | CCR3SLC1A2TSHRCYP2D6LMNA | |
| SCHEMBL7936483 | 0.86 | CCR3 (0.62) | CCR3SLC1A2CYP2D6 | |
| SCHEMBL7935328 | 0.85 | CCR3 (0.58) | CCR3NPSR1LMNAMAPT | |
| SCHEMBL7938443 | 0.84 | CCR3 (0.72) | CCR3SLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6191135-B1 | Neurokinin antagonists | BOEHRINGER INGELHEIM KG (DE) | 2001-02-20 | — | — | US | claimed |
| US-6191135-B1 | Neurokinin antagonists | BOEHRINGER INGELHEIM KG (DE) | 2001-02-20 | — | — | US | disclosed |
| US-5985881-A | TREATMENT AND PREVENTION OF RESPIRATORY DISORDERS, INFLAMMATORY EYE DISEASES, INFLAMMATORY SKIN DISEASES, INTESTINAL DISORDERS, OTHER INFLAMMATORY DISEASES | BOEHRINGER INGELHEIM KG (DE) | 1999-11-16 | — | — | US | disclosed |