Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.44 |
| ▸ | MEN1 | O00255 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7988320 | 1.00 | MAPT (0.44) | MAPTMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL7987213 | 0.90 | MAPT (0.42) | MAPTMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL7987215 | 0.90 | MAPT (0.42) | MAPTMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL7983690 | 0.76 | MAPT (0.49) | MAPTMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL7987146 | 0.73 | CYP19A1 (0.62) | MAPTMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL7987151 | 0.73 | CYP19A1 (0.62) | MAPTMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL15756387 | 0.73 | MAPT (0.50) | MAPTMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL7987242 | 0.72 | MEN1 (0.43) | MAPTMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL7987238 | 0.72 | MEN1 (0.43) | MAPTMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL6291705 | 0.70 | PARP1 (0.47) | MAPTMEN1KMT2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |