Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7687 | 0.94 | TLR8 (0.48) | TLR8HPGDUSP2SMN1; SMN2CHRM2 | |
| SCHEMBL6221438 | 0.94 | TLR8 (0.48) | TLR8HPGDUSP2SMN1; SMN2CHRM2 | |
| SCHEMBL943825 | 0.90 | TLR8 (0.47) | TLR8USP2SMN1; SMN2CHRM2CHRM1 | |
| SCHEMBL6486601 | 0.89 | MEN1 (0.45) | TLR8MEN1KMT2AHPGDUSP2 | |
| SCHEMBL18751236 | 0.88 | TLR8 (0.47) | TLR8USP2SMN1; SMN2CHRM2CHRM1 | |
| SCHEMBL29263655 | 0.88 | TLR8 (0.47) | TLR8USP2SMN1; SMN2CHRM2CHRM1 | |
| SCHEMBL12264373 | 0.88 | TLR8 (0.47) | TLR8USP2SMN1; SMN2CHRM2CHRM1 | |
| SCHEMBL27317678 | 0.87 | MEN1 (0.46) | TLR8MEN1KMT2AHPGDUSP2 | |
| SCHEMBL15984560 | 0.87 | MEN1 (0.41) | TLR8MEN1KMT2AHPGDUSP2 | |
| SCHEMBL17782085 | 0.86 | HPGD (0.49) | TLR8MEN1KMT2AHPGDUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235731-B1 | REDUCING BLOOD LIPIDS, SUGARS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-22 | — | — | US | disclosed |
| EP-0915888-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | Takeda Chemical Industries, Ltd. (JP) | 1999-05-19 | — | — | EP | disclosed |
| WO-1997040051-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-10-30 | — | — | WO | disclosed |