Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 11/20 | 0.77 |
| ▸ | SRC | P12931 | 3/20 | 0.77 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.52 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.52 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7986454 | 0.98 | FGFR1 (0.74) | FGFR1SRCHTTALDH1A1HPGD | |
| SCHEMBL19848102 | 0.87 | FGFR1 (0.68) | FGFR1SRCHTTALDH1A1HPGD | |
| SCHEMBL31294913 | 0.87 | FGFR1 (0.68) | FGFR1SRCHTTALDH1A1HPGD | |
| SCHEMBL7993203 | 0.87 | FGFR1 (1.00) | FGFR1SRCHTT | |
| Hydrochloric Acid SCHEMBL7987721 | 0.85 | FGFR1 (0.97) | FGFR1SRCHTT | |
| SCHEMBL23846263 | 0.81 | FGFR1 (0.76) | FGFR1SRCHTTALDH1A1HPGD | |
| SCHEMBL7986240 | 0.79 | FGFR1 (0.81) | FGFR1SRCHTTALDH1A1HPGD | |
| SCHEMBL7989553 | 0.79 | FGFR1 (1.00) | FGFR1SRCALDH1A1 | |
| Bromide SCHEMBL7987551 | 0.78 | FGFR1 (0.97) | FGFR1SRCALDH1A1 | |
| Hydrochloric Acid SCHEMBL7976259 | 0.78 | FGFR1 (0.78) | FGFR1SRCHTTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218388-B1 | THERAPY OF PROTEIN TYROSINE KINASE MEDIATED CANCER, ATHEROSCLEROSIS, RESTENOSIS, AND PSORIASIS BY ADMINISTERING BENZIMIDAZOLE DERIVATIVE | WARNER-LAMBERT COMPANY | 2001-04-17 | — | — | US | disclosed |
| US-5990146-A | TREATING PROTEIN TYROSINE KINASE MEDIATED CANCER; ANTICARCINOGENIC AGENTS; ATHEROSCLEROSIS; RESTENOSIS; PSORIASIS; ANTIPROLIFERATIVE AGENTS | WARNER-LAMBERT COMPANY (US) | 1999-11-23 | — | — | US | disclosed |