Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 15/20 | 0.50 |
| ▸ | DPP4 | P27487 | 2/20 | 0.50 |
| ▸ | PREP | P48147 | 1/20 | 0.43 |
| ▸ | FAP | Q12884 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7990129 | 0.92 | HDAC8 (0.48) | HDAC8DPP4PREPFAP | |
| SCHEMBL7990125 | 0.92 | HDAC8 (0.48) | HDAC8DPP4PREPFAP | |
| SCHEMBL7977929 | 0.90 | HDAC8 (0.47) | HDAC8DPP4FAP | |
| SCHEMBL7989903 | 0.89 | HDAC8 (0.53) | HDAC8DPP4 | |
| SCHEMBL7989905 | 0.89 | HDAC8 (0.53) | HDAC8DPP4 | |
| SCHEMBL7995839 | 0.89 | DPP4 (0.64) | HDAC8DPP4PREPFAP | |
| SCHEMBL7977842 | 0.89 | DPP4 (0.64) | HDAC8DPP4PREPFAP | |
| SCHEMBL7988600 | 0.88 | HDAC8 (0.52) | HDAC8DPP4PREP | |
| SCHEMBL7988401 | 0.85 | DPP4 (0.48) | HDAC8DPP4PREPFAP | |
| SCHEMBL7988406 | 0.85 | DPP4 (0.48) | HDAC8DPP4PREPFAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6172081-B1 | DIPEPTIDYL PEPTIDASE-IV INHIBITORS; NON-INSULIN DEPENDENT DIABETES | NOVARTIS AG (CH) | 2001-01-09 | — | — | US | disclosed |