Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 6/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.77 |
| ▸ | MAPT | P10636 | 5/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.77 |
| ▸ | THRB | P10828 | 2/20 | 0.77 |
| ▸ | HPGD | P15428 | 2/20 | 0.77 |
| ▸ | AKR1C3 | P42330 | 11/20 | 0.68 |
| ▸ | AKR1C2 | P52895 | 11/20 | 0.68 |
| ▸ | PRKCI | P41743 | 1/20 | 0.63 |
| ▸ | GFER | P55789 | 4/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.54 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.54 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2342942 | 0.87 | GAA (1.00) | GAAKDM4EMAPTALDH1A1HSD17B10 | |
| SCHEMBL11791985 | 0.87 | GAA (0.81) | GAAKDM4EMAPTALDH1A1HSD17B10 | |
| SCHEMBL9071956 | 0.85 | AKR1C3 (0.69) | GAAKDM4EMAPTALDH1A1HSD17B10 | |
| SCHEMBL121984 | 0.84 | PRKCI (0.59) | GAAKDM4EMAPTALDH1A1HSD17B10 | |
| SCHEMBL4002584 | 0.84 | GAA (0.72) | GAAKDM4EMAPTALDH1A1HSD17B10 | |
| SCHEMBL11391871 | 0.84 | AKR1C3 (0.68) | GAAKDM4EMAPTALDH1A1HSD17B10 | |
| SCHEMBL4286847 | 0.84 | GAA (0.77) | GAAKDM4EMAPTALDH1A1HSD17B10 | |
| SCHEMBL2651013 | 0.84 | PRKCI (0.55) | GAAKDM4EMAPTALDH1A1HSD17B10 | |
| SCHEMBL2649113 | 0.84 | PRKCI (0.55) | GAAKDM4EMAPTALDH1A1HSD17B10 | |
| SCHEMBL9683164 | 0.83 | GAA (0.70) | GAAKDM4EMAPTALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218388-B1 | THERAPY OF PROTEIN TYROSINE KINASE MEDIATED CANCER, ATHEROSCLEROSIS, RESTENOSIS, AND PSORIASIS BY ADMINISTERING BENZIMIDAZOLE DERIVATIVE | WARNER-LAMBERT COMPANY | 2001-04-17 | — | — | US | disclosed |