SCHEMBL7990844 — predicted protein targets

Predicted protein targets (top 12)

	gene	UniProt	supporting neighbours	confidence
▸	KDR	P35968	9/20	0.78

▸	FLT1	P17948	5/20	0.78

▸	FLT4	P35916	5/20	0.78

▸	NFATC1	O95644	1/20	0.43

▸	GSK3B	P49841	1/20	0.43

▸	DYRK1A	Q13627	1/20	0.43

▸	TMEM97	Q5BJF2	5/20	0.41

▸	CYP2A6	P11509	1/20	0.39

▸	HRH3	Q9Y5N1	2/20	0.35

▸	DRD2	P14416	1/20	0.35

▸	DRD3	P35462	1/20	0.35

▸	TDP2	O95551	1/20	0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL7557243	0.94	KDR (0.77)	KDRFLT1FLT4NFATC1GSK3B
SCHEMBL7976990	0.93	KDR (0.78)	KDRFLT1FLT4NFATC1GSK3B
SCHEMBL7551305	0.93	KDR (0.78)	KDRFLT1FLT4NFATC1GSK3B
SCHEMBL7554305	0.88	KDR (0.60)	KDRFLT1FLT4NFATC1GSK3B
SCHEMBL7554703	0.88	KDR (1.00)	KDRFLT1FLT4NFATC1GSK3B
SCHEMBL7551421	0.87	KDR (0.77)	KDRFLT1FLT4NFATC1GSK3B
SCHEMBL7554686	0.87	KDR (0.63)	KDRFLT1FLT4NFATC1GSK3B
SCHEMBL7993928	0.86	KDR (0.78)	KDRFLT1FLT4NFATC1GSK3B
SCHEMBL7550391	0.86	KDR (0.59)	KDRFLT1FLT4NFATC1GSK3B
SCHEMBL7550302	0.85	KDR (0.78)	KDRFLT1FLT4NFATC1GSK3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-6265403-B1	TYROSINE INHIBITORS	MERCK & CO., INC.	2001-07-24	—	—	US	disclosed