Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 7/20 | 0.49 |
| ▸ | SRC | P12931 | 5/20 | 0.49 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.45 |
| ▸ | SYK | P43405 | 2/20 | 0.45 |
| ▸ | RET | P07949 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | RGS12 | O14924 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GMNN | O75496 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | YES1 | P07947 | 1/20 | 0.45 |
| ▸ | LYN | P07948 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5840677 | 0.96 | PDPK1 (0.50) | PDPK1SRCMAP4K1SIRT1NTRK1 | |
| SCHEMBL5840674 | 0.96 | PDPK1 (0.50) | PDPK1SRCMAP4K1SIRT1NTRK1 | |
| SCHEMBL5179937 | 0.88 | SRC (0.63) | PDPK1SRCMAP4K1SIRT1NTRK1 | |
| SCHEMBL5179933 | 0.88 | SRC (0.63) | PDPK1SRCMAP4K1SIRT1NTRK1 | |
| SCHEMBL6394720 | 0.85 | PDPK1 (0.65) | PDPK1SRCMAP4K1SIRT1NTRK1 | |
| SCHEMBL6394717 | 0.85 | PDPK1 (0.65) | PDPK1SRCMAP4K1SIRT1NTRK1 | |
| SCHEMBL5182990 | 0.84 | SRC (0.63) | PDPK1SRCMAP4K1SIRT1NTRK1 | |
| SCHEMBL5182993 | 0.84 | SRC (0.63) | PDPK1SRCMAP4K1SIRT1NTRK1 | |
| SCHEMBL6704774 | 0.84 | KDR (0.54) | PDPK1SRCMAP4K1SIRT1NTRK1 | |
| SCHEMBL6704775 | 0.84 | KDR (0.54) | PDPK1SRCMAP4K1SIRT1NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000008202-A9 | 3-METHYLIDENYL-2-INDOLINONE MODULATORS OF PROTEIN KINASE | SUGEN INC (US) | 2000-07-27 | — | — | WO | disclosed |