Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 20/20 | 0.62 |
| ▸ | MAPK13 | O15264 | 11/20 | 0.62 |
| ▸ | MAPK12 | P53778 | 11/20 | 0.62 |
| ▸ | MAPK11 | Q15759 | 11/20 | 0.62 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.62 |
| ▸ | RAF1 | P04049 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7993953 | 0.95 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7979937 | 0.91 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7990822 | 0.90 | MAPK14 (0.65) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7994015 | 0.90 | MAPK14 (0.63) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7994010 | 0.90 | MAPK14 (0.63) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL6950332 | 0.89 | MAPK14 (0.65) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7991937 | 0.87 | MAPK14 (0.67) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7994418 | 0.82 | MAPK14 (0.70) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7997413 | 0.82 | MAPK14 (0.63) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7979995 | 0.81 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291457-B1 | SUBSTITUTED IMIDAZOLE COMPOUNDS | MERCK & CO., INC. | 2001-09-18 | — | — | US | disclosed |