SCHEMBL7992833

SCHEMBL7992833

CC[C@H]1CC[C@H](COC2(c3ccc(Cl)cc3)c3ccccc3C(=O)N2Cc2ccc([N+](=O)[O-])cc2)CC1

nearest known ligand 0.86

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MDM2 Q00987 20/20 0.86
TP53 P04637 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20099591 0.94 MDM2 (0.84) MDM2TP53
SCHEMBL7989820 0.93 MDM2 (0.85) MDM2TP53
SCHEMBL12305350 0.92 MDM2 (1.00) MDM2TP53
SCHEMBL2454016 0.92 MDM2 (1.00) MDM2TP53
SCHEMBL1819435 0.84 MDM2 (1.00) MDM2TP53
SCHEMBL7993858 0.84 MDM2 (1.00) MDM2TP53
SCHEMBL12332981 0.83 MDM2 (0.73) MDM2TP53
SCHEMBL1821391 0.82 MDM2 (1.00) MDM2TP53
SCHEMBL12305352 0.82 MDM2 (1.00) MDM2TP53
SCHEMBL12333073 0.82 MDM2 (0.89) MDM2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009156735-A2 NEW THERAPEUTIC AGENTS CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2009-12-30 WO disclosed