Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | CNR2 | P34972 | 4/20 | 0.59 |
| ▸ | FAAH | O00519 | 2/20 | 0.58 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.57 |
| ▸ | CNR1 | P21554 | 2/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.56 |
| ▸ | BCHE | P06276 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7228750 | 0.86 | MAPT (0.61) | NPC1RAB9ACNR2CYP19A1CNR1 | |
| SCHEMBL3295875 | 0.80 | CYP19A1 (0.65) | NPC1RAB9ACNR2FAAHCYP19A1 | |
| SCHEMBL810591 | 0.79 | NPC1 (0.51) | NPC1RAB9ACNR2CYP19A1CNR1 | |
| SCHEMBL9185336 | 0.79 | NPC1 (0.51) | NPC1RAB9ACNR2CYP19A1CNR1 | |
| SCHEMBL6841709 | 0.78 | CYP19A1 (0.66) | NPC1RAB9ACNR2CYP19A1CNR1 | |
| SCHEMBL2965418 | 0.78 | MAOB (0.63) | RAB9AMAPTMEN1KMT2ACHRNB2 | |
| SCHEMBL30443578 | 0.78 | MAOB (0.63) | RAB9AMAPTMEN1KMT2ACHRNB2 | |
| SCHEMBL5609808 | 0.77 | NPC1 (0.64) | NPC1RAB9ACNR2CNR1MAPT | |
| SCHEMBL15249123 | 0.76 | NPC1 (0.64) | NPC1RAB9ACNR2CNR1MEN1 | |
| SCHEMBL15249111 | 0.76 | NPC1 (0.63) | NPC1RAB9ACNR2CNR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0817629-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2000-03-08 | — | — | EP | disclosed |
| EP-0817629-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-01-14 | — | — | EP | disclosed |
| US-5631280-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1997-05-20 | — | — | US | disclosed |
| WO-1996030014-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1996-10-03 | — | — | WO | disclosed |