Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLCG2 | P16885 | 2/20 | 0.67 |
| ▸ | APEX1 | P27695 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 5/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | THRB | P10828 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.51 |
| ▸ | PYGL | P06737 | 1/20 | 0.48 |
| ▸ | PYGM | P11217 | 1/20 | 0.48 |
| ▸ | FBP1 | P09467 | 3/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7991465 | 0.84 | PLCG2 (0.60) | PLCG2APEX1MAPTMAPK1NPC1 | |
| SCHEMBL6215530 | 0.83 | APEX1 (0.70) | PLCG2APEX1MAPTMAPK1NPC1 | |
| SCHEMBL2304168 | 0.80 | PLCG2 (1.00) | PLCG2APEX1MAPTMAPK1NPC1 | |
| SCHEMBL7991526 | 0.80 | HRH4 (0.47) | PLCG2MAPTMAPK1HRH4PYGL | |
| SCHEMBL7991463 | 0.79 | MAPT (0.58) | PLCG2APEX1MAPTMAPK1NPC1 | |
| SCHEMBL1277212 | 0.77 | APEX1 (1.00) | PLCG2APEX1MAPTMAPK1NPC1 | |
| SCHEMBL5268675 | 0.77 | APEX1 (1.00) | PLCG2APEX1MAPTMAPK1NPC1 | |
| SCHEMBL27964638 | 0.77 | PLCG2 (0.64) | PLCG2APEX1MAPTMAPK1NPC1 | |
| SCHEMBL1653052 | 0.76 | APEX1 (0.76) | PLCG2APEX1MAPTMAPK1NPC1 | |
| SCHEMBL1653100 | 0.76 | PLCG2 (0.69) | PLCG2APEX1MAPTMAPK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294672-B1 | FOR THERAPY OF DIABETES, AND OTHER DISEASES WHERE THE INHIBITION OF GLUCONEOGENESIS, CONTROL OF BLOOD GLUCOSE LEVELS, REDUCTION IN GLYCOGEN STORES, OR REDUCTION IN INSULIN LEVELS IS BENEFICIAL | METABASIS THERAPEUTICS, INC. | 2001-09-25 | — | — | US | disclosed |
| US-6054587-A | ANTIDIABETIC AGENTS | METABASIS THERAPEUTICS, INC. (US) | 2000-04-25 | — | — | US | disclosed |
| WO-1998039342-A1 | NOVEL INDOLE AND AZAINDOLE INHIBITORS OF FRUCTOSE-1,6-BISPHOSPHATASE | METABASIS THERAPEUTICS, INC. (US) | 1998-09-11 | — | — | WO | disclosed |