Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 3/20 | 0.62 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.62 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.62 |
| ▸ | PRKDC | P78527 | 2/20 | 0.62 |
| ▸ | RICTOR | Q6R327 | 2/20 | 0.62 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.62 |
| ▸ | MAPKAP1 | Q9BPZ7 | 2/20 | 0.62 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.62 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.62 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | NQO2 | P16083 | 1/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.47 |
| ▸ | FECH | P22830 | 1/20 | 0.47 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.47 |
| ▸ | BMPR2 | Q13873 | 1/20 | 0.47 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6942812 | 0.89 | PIK3CA (0.79) | MTORPIK3CAPIK3CGPRKDCRICTOR | |
| SCHEMBL13962513 | 0.79 | MTOR (0.57) | MTORPIK3CAPIK3CGPRKDCRICTOR | |
| SCHEMBL14536973 | 0.78 | MTOR (0.51) | MTORPIK3CAPIK3CGPRKDCRICTOR | |
| SCHEMBL6943372 | 0.78 | PIK3CA (0.82) | MTORPIK3CAPIK3CGPRKDCRICTOR | |
| SCHEMBL6944582 | 0.78 | MTOR (0.76) | MTORPIK3CAPIK3CGPRKDCRICTOR | |
| SCHEMBL13962745 | 0.78 | PIK3CA (0.85) | MTORPIK3CAPIK3CGPRKDCRICTOR | |
| SCHEMBL13962787 | 0.77 | FGFR1 (0.52) | MTORPIK3CAPIK3CGPRKDCRICTOR | |
| SCHEMBL8064575 | 0.77 | PIK3CA (0.81) | MTORPIK3CAPIK3CGPRKDCRICTOR | |
| SCHEMBL6943564 | 0.77 | PIK3CA (0.81) | MTORPIK3CAPIK3CGPRKDCRICTOR | |
| SCHEMBL6942690 | 0.77 | PIK3CA (0.84) | MTORPIK3CAPIK3CGPRKDCRICTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117482-A1 | MTOR INHIBITOR SALT FORMS | OSI PHARMACEUTICALS, INC (US) | 2009-09-24 | — | — | WO | disclosed |