Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.75 |
| ▸ | FLT1 | P17948 | 5/20 | 0.54 |
| ▸ | FLT4 | P35916 | 5/20 | 0.54 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 4/20 | 0.44 |
| ▸ | HTR6 | P50406 | 3/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | QPCT | Q16769 | 3/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7990876 | 0.88 | KDR (0.56) | KDRPRKD1TDP1GSK3BHTR6 | |
| SCHEMBL7512866 | 0.87 | KDR (0.60) | KDRFLT1FLT4PRKD1TDP1 | |
| SCHEMBL7987071 | 0.86 | KDR (0.56) | KDRPRKD1TDP1GSK3BHTR6 | |
| SCHEMBL7553991 | 0.85 | KDR (1.00) | KDRFLT1FLT4PRKD1TDP1 | |
| SCHEMBL7545744 | 0.85 | KDR (0.75) | KDRFLT1FLT4GSK3BPIK3CA | |
| SCHEMBL7986701 | 0.85 | KDR (0.53) | KDRPRKD1TDP1GSK3BHTR6 | |
| SCHEMBL7986894 | 0.85 | KDR (0.74) | KDRFLT1FLT4GSK3BQPCT | |
| SCHEMBL7507635 | 0.84 | KDR (0.73) | KDRFLT1FLT4TDP1HTR6 | |
| SCHEMBL7550053 | 0.84 | KDR (0.75) | KDRFLT1FLT4HTR6ALPL | |
| SCHEMBL7990663 | 0.83 | KDR (0.73) | KDRFLT1FLT4HTR6ALPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |