Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 20/20 | 0.78 |
| ▸ | LITAF | Q99732 | 20/20 | 0.78 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.78 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8003242 | 0.93 | TNF (0.80) | TNFLITAFPDE4BPDE4D | |
| SCHEMBL7995474 | 0.90 | TNF (0.85) | TNFLITAFPDE4BPDE4D | |
| SCHEMBL2015231 | 0.89 | TNF (0.81) | TNFLITAFPDE4BPDE4D | |
| SCHEMBL2018697 | 0.89 | TNF (0.84) | TNFLITAFPDE4BPDE4D | |
| SCHEMBL2019512 | 0.88 | TNF (1.00) | TNFLITAFPDE4BPDE4D | |
| SCHEMBL2016579 | 0.88 | TNF (1.00) | TNFLITAFPDE4BPDE4D | |
| SCHEMBL2014882 | 0.88 | TNF (1.00) | TNFLITAFPDE4BPDE4D | |
| SCHEMBL2021197 | 0.88 | TNF (1.00) | TNFLITAFPDE4BPDE4D | |
| SCHEMBL2016764 | 0.87 | TNF (0.76) | TNFLITAFPDE4BPDE4D | |
| SCHEMBL2017319 | 0.87 | TNF (0.81) | TNFLITAFPDE4BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009094528-A1 | TRICYCLIC COMPOUNDS AS MODULATORS OF TNF-α SYNTHESIS AND AS PDE4 INHIBITORS | HIGH POINT PHARMACEUTICALS, LLC (US) | 2009-07-30 | — | — | WO | disclosed |