Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN7 | P35236 | 5/20 | 0.40 |
| ▸ | HMGCR | P04035 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3858349 | 1.00 | PTPN7 (0.40) | PTPN7HMGCRRAB9ARECQLTDP1 | |
| SCHEMBL8668772 | 1.00 | PTPN7 (0.40) | PTPN7HMGCRRAB9ARECQLTDP1 | |
| SCHEMBL3861203 | 1.00 | PTPN7 (0.40) | PTPN7HMGCRRAB9ARECQLTDP1 | |
| SCHEMBL3858554 | 1.00 | PTPN7 (0.40) | PTPN7HMGCRRAB9ARECQLTDP1 | |
| SCHEMBL3206990 | 1.00 | PTPN7 (0.40) | PTPN7HMGCRRAB9ARECQLTDP1 | |
| SCHEMBL1116731 | 0.97 | PTPN7 (0.37) | PTPN7HMGCRRAB9ARECQLTDP1 | |
| SCHEMBL16416623 | 0.93 | RECQL (0.46) | PTPN7HMGCRRAB9ARECQLTDP1 | |
| SCHEMBL9681594 | 0.90 | PTPN7 (0.50) | PTPN7HMGCRRAB9ARECQLTDP1 | |
| SCHEMBL61256 | 0.90 | PTPN7 (0.50) | PTPN7HMGCRRAB9ARECQLTDP1 | |
| SCHEMBL8669383 | 0.90 | PTPN7 (0.50) | PTPN7HMGCRRAB9ARECQLTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6284784-B1 | 2-HYDROXYMETHYL DERIVATIVES | GEORGETOWN UNIVERSITY | 2001-09-04 | — | — | US | disclosed |
| EP-1015427-A1 | SUBSTITUTED 2-PYRROLIDINONE ACTIVATORS OF PKC | GEORGETOWN UNIVERSITY (US) | 2000-07-05 | — | — | EP | disclosed |
| US-5962504-A | ACTIVATOR OF PROTEIN KINASE; ANTICANCER AGENT | GEORGETOWN UNIVERSITY (US) | 1999-10-05 | — | — | US | disclosed |
| WO-1999012901-A1 | SUBSTITUTED 2-PYRROLIDINONE ACTIVATORS OF PKC | GEORGETOWN UNIVERSITY (US) | 1999-03-18 | — | — | WO | disclosed |