Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 18/20 | 0.54 |
| ▸ | MTOR | P42345 | 9/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.50 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.49 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.49 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | RICTOR | Q6R327 | 2/20 | 0.46 |
| ▸ | MAPKAP1 | Q9BPZ7 | 2/20 | 0.46 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13382895 | 0.80 | PIK3CA (0.52) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL335833 | 0.80 | PIK3CA (0.53) | PIK3CAMTORPIK3CDPIK3CBPIK3R1 | |
| SCHEMBL335785 | 0.77 | PIK3CA (0.57) | PIK3CAMTORPIK3CDPIK3CBPIK3R1 | |
| SCHEMBL1113697 | 0.75 | PIK3CA (0.59) | PIK3CAMTORPIK3CDPIK3CBPIK3R1 | |
| SCHEMBL336882 | 0.74 | PIK3CA (0.54) | PIK3CAMTORPIK3CDPIK3CBPIK3R1 | |
| SCHEMBL336555 | 0.73 | PIK3CA (0.58) | PIK3CAMTORPIK3CDPIK3CBPIK3R1 | |
| SCHEMBL336657 | 0.73 | PIK3CA (0.61) | PIK3CAMTORPIK3CDPIK3CBPIK3R1 | |
| SCHEMBL1114084 | 0.73 | PIK3CA (0.61) | PIK3CAMTORPIK3CDPIK3CBPIK3R1 | |
| SCHEMBL336661 | 0.72 | PIK3CA (0.53) | PIK3CAMTORPIK3CDPIK3CBPIK3R1 | |
| SCHEMBL2873223 | 0.71 | PIK3CA (0.51) | PIK3CAMTORPIK3CDPIK3CBPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8309546-B2 | Morpholinopurine derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-11-13 | — | — | US | disclosed |
| US-8309546-B2 | Morpholinopurine derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-11-13 | — | — | US | disclosed |
| US-20120071476-A1 | MORPHOLINOPURINE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-03-22 | — | — | US | disclosed |
| US-20120071476-A1 | MORPHOLINOPURINE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-03-22 | — | — | US | disclosed |
| US-8097622-B2 | Morpholinopurine derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-01-17 | — | — | US | disclosed |
| US-8097622-B2 | Morpholinopurine derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-01-17 | — | — | US | disclosed |
| US-20100130492-A1 | MORPHOLINOPURINE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-05-27 | — | — | US | disclosed |
| US-20100130492-A1 | MORPHOLINOPURINE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130492-A1 | MORPHOLINOPURINE DERIVATIVES | MTOR, RICTOR, PIK3R1 | PIK3CA 22/4885MTOR 1/4885PIK3CD 46/4885 |
| US-20120071476-A1 | MORPHOLINOPURINE DERIVATIVES | MTOR, RICTOR, PIK3R1 | PIK3CA 22/4885MTOR 1/4885PIK3CD 46/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.