Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 18/20 | 0.48 |
| ▸ | PREP | P48147 | 1/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | F7 | P08709 | 2/20 | 0.42 |
| ▸ | F3 | P13726 | 2/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31486475 | 0.89 | PREP (0.43) | F2PREPMAPK14 | |
| SCHEMBL6740598 | 0.87 | F2 (0.46) | F2PRSS1 | |
| SCHEMBL6734250 | 0.82 | F2 (0.44) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL31486336 | 0.82 | AOC3 (0.42) | PREPMAPK14 | |
| SCHEMBL6073947 | 0.81 | ACE (0.35) | F2PREPF7F3 | |
| SCHEMBL31565033 | 0.80 | NPFFR1 (0.37) | F2PREP | |
| SCHEMBL31486227 | 0.79 | JAK3 (0.43) | PREP | |
| SCHEMBL6991514 | 0.79 | F2 (0.64) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL6994201 | 0.79 | F2 (0.64) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL6997888 | 0.79 | F2 (0.64) | F2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6277851-B1 | ORALLY ADMINISTERED TRYPSIN-RELATED SERINE PROTEASE INHIBITORS; ANTICOAGULANTS | ADIR ET COMPAGNIE (FR) | 2001-08-21 | — | — | US | disclosed |