Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | EDNRA | P25101 | 1/20 | 0.39 |
| ▸ | GPR139 | Q6DWJ6 | 3/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | CASR | P41180 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7995948 | 1.00 | MEN1 (0.41) | MEN1KMT2AROCK2ROCK1EDNRA | |
| SCHEMBL8005152 | 0.94 | PDE4B (0.45) | MEN1KMT2AROCK2ROCK1EDNRA | |
| SCHEMBL8004576 | 0.94 | PDE4B (0.45) | MEN1KMT2AROCK2ROCK1EDNRA | |
| SCHEMBL8007232 | 0.88 | PDE4B (0.41) | MEN1KMT2AROCK2ROCK1PDE4B | |
| SCHEMBL7995664 | 0.88 | PDE4B (0.41) | MEN1KMT2AROCK2ROCK1PDE4B | |
| SCHEMBL7763145 | 0.87 | EDNRA (0.41) | MEN1KMT2AROCK2ROCK1EDNRA | |
| SCHEMBL7765376 | 0.87 | EDNRA (0.41) | MEN1KMT2AROCK2ROCK1EDNRA | |
| SCHEMBL7760417 | 0.82 | PDE4B (0.43) | MEN1KMT2AROCK2ROCK1EDNRA | |
| SCHEMBL7764572 | 0.82 | PDE4B (0.43) | MEN1KMT2AROCK2ROCK1EDNRA | |
| SCHEMBL7763963 | 0.76 | PDE4A (0.40) | MEN1KMT2AEDNRAPDE4BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6025376-A | INHIBITORS OF TUMOR NECROSIS FACTOR, TREATING MULTIPLE SCLEROSIS | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-02-15 | — | — | US | disclosed |