Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 14/20 | 0.44 |
| ▸ | MTOR | P42345 | 14/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.44 |
| ▸ | PIK3R1 | P27986 | 7/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | RPTOR | Q8N122 | 6/20 | 0.36 |
| ▸ | MLST8 | Q9BVC4 | 6/20 | 0.36 |
| ▸ | RICTOR | Q6R327 | 4/20 | 0.36 |
| ▸ | MAPKAP1 | Q9BPZ7 | 4/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL799244 | 0.90 | MTOR (0.47) | PIK3CAMTORPIK3CDPIK3R1PIK3CB | |
| SCHEMBL799608 | 0.87 | PIK3CA (0.38) | PIK3CAMTORPIK3CDPIK3R1RPTOR | |
| SCHEMBL27860348 | 0.83 | MTOR (0.43) | PIK3CAMTORPIK3CDPIK3R1ATR | |
| SCHEMBL799327 | 0.82 | MTOR (0.52) | PIK3CAMTORPIK3CDPIK3R1ATR | |
| SCHEMBL799510 | 0.81 | MTOR (0.52) | PIK3CAMTORPIK3CDPIK3R1PIK3CB | |
| SCHEMBL799241 | 0.79 | MTOR (0.49) | PIK3CAMTORPIK3CDPIK3R1PIK3CB | |
| Isobutane SCHEMBL27860349 | 0.78 | MTOR (0.47) | PIK3CAMTORPIK3CDPIK3R1ATR | |
| SCHEMBL799161 | 0.77 | PIK3CA (0.48) | PIK3CAMTORPIK3CDPIK3R1PIK3CB | |
| SCHEMBL799279 | 0.76 | MTOR (0.52) | PIK3CAMTORPIK3CDPIK3R1PIK3CB | |
| SCHEMBL1114353 | 0.76 | MTOR (0.48) | PIK3CAMTORPIK3CDPIK3R1ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8309546-B2 | Morpholinopurine derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-11-13 | — | — | US | disclosed |
| US-20120071476-A1 | MORPHOLINOPURINE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-03-22 | — | — | US | disclosed |
| US-8097622-B2 | Morpholinopurine derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-01-17 | — | — | US | disclosed |
| US-8097622-B2 | Morpholinopurine derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-01-17 | — | — | US | disclosed |
| US-20100130492-A1 | MORPHOLINOPURINE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-05-27 | — | — | US | disclosed |
| US-20100130492-A1 | MORPHOLINOPURINE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-05-27 | — | — | US | disclosed |
| WO-2010044401-A1 | MORPHOLINOPURINE DERIVATIVE | 第一三共株式会社 (JP) | 2010-04-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130492-A1 | MORPHOLINOPURINE DERIVATIVES | MTOR, RICTOR, PIK3R1 | PIK3CA 22/4885MTOR 1/4885PIK3CD 46/4885 |
| US-20120071476-A1 | MORPHOLINOPURINE DERIVATIVES | MTOR, RICTOR, PIK3R1 | PIK3CA 22/4885MTOR 1/4885PIK3CD 46/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.