Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 11/20 | 0.64 |
| ▸ | MTOR | P42345 | 4/20 | 0.64 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17244452 | 0.84 | PIK3CA (0.62) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL1551287 | 0.84 | PIK3CA (0.74) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL1552109 | 0.84 | PIK3CA (0.64) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL1551282 | 0.83 | PIK3CA (0.74) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL3400082 | 0.82 | PIK3CA (0.58) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL1550849 | 0.82 | PIK3CA (0.60) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL17244488 | 0.81 | PIK3CA (0.59) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL3399984 | 0.81 | PIK3CA (0.59) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL8005706 | 0.80 | PIK3CA (0.58) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL13574303 | 0.79 | PIK3CA (0.57) | PIK3CAMTORPIK3R1PIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250160-B1 | THIOPHENES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE (PI3K) INHIBITORS | MILLENNIUM PHARM INC (US) | 2015-11-11 | — | — | EP | disclosed |
| WO-2009094224-A1 | THIOPHENES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE (PI3K) INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-07-30 | — | — | WO | disclosed |