Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 9/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.49 |
| ▸ | DRD2 | P14416 | 2/20 | 0.49 |
| ▸ | DRD3 | P35462 | 2/20 | 0.49 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.47 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7992799 | 0.88 | OPRL1 (0.75) | OPRL1CYP2D6MEN1CYP3A4CYP2C9 | |
| SCHEMBL7982285 | 0.83 | OPRL1 (0.69) | OPRL1CYP2D6MEN1CYP3A4CYP2C9 | |
| SCHEMBL7999841 | 0.83 | OPRL1 (0.69) | OPRL1CYP2D6MEN1CYP3A4CYP2C9 | |
| SCHEMBL7760219 | 0.83 | MEN1 (0.72) | OPRL1CYP2D6MEN1CYP3A4CYP2C9 | |
| SCHEMBL7982598 | 0.83 | OPRL1 (0.77) | OPRL1CYP2D6MEN1CYP3A4CYP2C9 | |
| SCHEMBL29766745 | 0.83 | OPRL1 (1.00) | OPRL1CYP2D6MEN1CYP3A4CYP2C9 | |
| SCHEMBL7757872 | 0.83 | OPRL1 (1.00) | OPRL1CYP2D6MEN1CYP3A4CYP2C9 | |
| SCHEMBL7992852 | 0.82 | OPRL1 (0.77) | OPRL1CYP2D6MEN1CYP3A4CYP2C9 | |
| SCHEMBL7992822 | 0.82 | OPRL1 (0.77) | OPRL1CYP2D6MEN1CYP3A4CYP2C9 | |
| SCHEMBL7999876 | 0.80 | OPRL1 (0.82) | OPRL1CYP2D6MEN1CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6277991-B1 | FOR TREATMENT OF MIGRAINE, NON-INSULIN DEPENDENT DIABETES MELLITUS, SEPSIS, INFLAMMATION, INCONTINENCE, VASOMOTOR DISTURBANCES SUCH AS HOT FLUSHES OR HOT FLASHES | NOVO NORDISK A/S (DK) | 2001-08-21 | — | — | US | disclosed |