Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 9/20 | 0.66 |
| ▸ | GAK | O14976 | 1/20 | 0.46 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.43 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13597832 | 0.93 | PIK3CA (0.70) | PIK3CAGAKPIK3R1BRAFGRIA2 | |
| SCHEMBL17244456 | 0.91 | PIK3CA (0.66) | PIK3CAGAKPIK3R1FYNGRIA2 | |
| SCHEMBL3400775 | 0.86 | PIK3CA (0.77) | PIK3CAPIK3R1GRIA2GRIA4ALDH1A1 | |
| SCHEMBL8005531 | 0.85 | PIK3CA (0.68) | PIK3CAGAKPIK3R1BRAFGRIA2 | |
| SCHEMBL8008648 | 0.85 | PIK3CA (0.66) | PIK3CAGAKPIK3R1GRIA2GRIA4 | |
| SCHEMBL3403823 | 0.82 | PIK3CA (0.80) | PIK3CAPIK3R1GRIA2GRIA4KDM4E | |
| SCHEMBL3404237 | 0.81 | PIK3CA (0.79) | PIK3CAPIK3R1GRIA2GRIA4LMNA | |
| SCHEMBL8006407 | 0.81 | PIK3CA (0.82) | PIK3CAPIK3R1GRIA2GRIA4 | |
| SCHEMBL7996628 | 0.80 | PIK3CA (0.80) | PIK3CAPIK3R1GRIA2GRIA4KDM4E | |
| SCHEMBL17244513 | 0.79 | PIK3CA (0.69) | PIK3CAPIK3R1GRIA2GRIA4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009094224-A1 | THIOPHENES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE (PI3K) INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-07-30 | — | — | WO | disclosed |