Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 12/20 | 0.74 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.63 |
| ▸ | PIM1 | P11309 | 2/20 | 0.62 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.62 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.60 |
| ▸ | MAOA | P21397 | 2/20 | 0.57 |
| ▸ | MAOB | P27338 | 2/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.57 |
| ▸ | ESRRA | P11474 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7996867 | 1.00 | HPGD (0.74) | HPGDCISD1PIM1PIM2PTPN1 | |
| SCHEMBL6381880 | 0.85 | HPGD (0.77) | HPGDCISD1PIM1PIM2PTPN1 | |
| SCHEMBL6381881 | 0.85 | HPGD (0.77) | HPGDCISD1PIM1PIM2PTPN1 | |
| SCHEMBL1300347 | 0.85 | HPGD (1.00) | HPGDCISD1PIM1PIM2PTPN1 | |
| SCHEMBL6866778 | 0.85 | HPGD (1.00) | HPGDCISD1PIM1PIM2PTPN1 | |
| SCHEMBL1300345 | 0.85 | HPGD (1.00) | HPGDCISD1PIM1PIM2PTPN1 | |
| SCHEMBL8003882 | 0.82 | HPGD (0.72) | HPGDCISD1PIM1PIM2PTPN1 | |
| SCHEMBL7996853 | 0.81 | HPGD (0.71) | HPGDCISD1PIM1PIM2PTPN1 | |
| SCHEMBL7996857 | 0.81 | HPGD (0.71) | HPGDCISD1PIM1PIM2PTPN1 | |
| SCHEMBL8003791 | 0.81 | HPGD (0.71) | HPGDCISD1PIM1PIM2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288096-B1 | ANTIDIABETIC AGENTS, HYPOTENSIVE AGENTS, AND ANTICHOLESTEROL AGENTS | ASTRAZENECA AB (SE) | 2001-09-11 | — | — | US | disclosed |